Gastroenterology
CPT 45378 vs 45380
Colonoscopy vs Colonoscopy with Biopsy — side-by-side RVU comparison with clinical guidance on when to use each code.
Key Difference
The biopsy add-on (45380) increases the RVU value to reflect the additional technical skill and time required for tissue sampling during the procedure.
Clinical Documentation Tip
Code the most comprehensive intervention performed. If both biopsy and polypectomy are done, the higher-value polypectomy code takes precedence.
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